Pallidal spiking activity reflects learning dynamics and predicts performance
Identifieur interne : 000258 ( Main/Exploration ); précédent : 000257; suivant : 000259Pallidal spiking activity reflects learning dynamics and predicts performance
Auteurs : Eitan Schechtman [Israël] ; Maria Imelda Noblejas [Israël] ; Aviv D. Mizrahi [Israël] ; Omer Dauber [Israël] ; Hagai Bergman [Israël]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2016.
Abstract
The basal ganglia (BG) are a set of interconnected nuclei deeply buried within the brain that are involved in action selection and habit formation. Classically considered motor nuclei, their role in cognitive performance has become widely appreciated over time. Current models of learning in the BG focus on striatal neurons and the neurotransmitter dopamine, but these do not fully account for observed behaviors. In this paper, we considered the learning-related activity of the external globus pallidus (GPe), a downstream BG nucleus. We show that GPe spiking activity predicts future performance, corresponds with learning dynamics, and decreases as performance becomes more automatic. Taken together, our data reveal the role of GPe in learning and open new avenues for research.
Url:
DOI: 10.1073/pnas.1612392113
PubMed: 27671661
PubMed Central: 5068334
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000676
- to stream Pmc, to step Curation: 000676
- to stream Pmc, to step Checkpoint: 000085
- to stream Ncbi, to step Merge: 002096
- to stream Ncbi, to step Curation: 002096
- to stream Ncbi, to step Checkpoint: 002096
- to stream Main, to step Merge: 000259
- to stream Main, to step Curation: 000258
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pallidal spiking activity reflects learning dynamics and predicts performance</title><author><name sortKey="Schechtman, Eitan" sort="Schechtman, Eitan" uniqKey="Schechtman E" first="Eitan" last="Schechtman">Eitan Schechtman</name><affiliation wicri:level="1"><nlm:aff id="aff1">Edmond and Lily Safra Centre for Brain Sciences,<institution>The Hebrew University of Jerusalem</institution>, Safra Campus, Jerusalem,<country>Israel</country> 9190401;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Noblejas, Maria Imelda" sort="Noblejas, Maria Imelda" uniqKey="Noblejas M" first="Maria Imelda" last="Noblejas">Maria Imelda Noblejas</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurobiology, Institute of Medical Research-Israel Canada, Hadassah Medical School,<institution>The Hebrew University of Jerusalem</institution>, Jerusalem,<country>Israel</country> 9112001</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizrahi, Aviv D" sort="Mizrahi, Aviv D" uniqKey="Mizrahi A" first="Aviv D." last="Mizrahi">Aviv D. Mizrahi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurobiology, Institute of Medical Research-Israel Canada, Hadassah Medical School,<institution>The Hebrew University of Jerusalem</institution>, Jerusalem,<country>Israel</country> 9112001</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dauber, Omer" sort="Dauber, Omer" uniqKey="Dauber O" first="Omer" last="Dauber">Omer Dauber</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurobiology, Institute of Medical Research-Israel Canada, Hadassah Medical School,<institution>The Hebrew University of Jerusalem</institution>, Jerusalem,<country>Israel</country> 9112001</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><affiliation wicri:level="1"><nlm:aff id="aff1">Edmond and Lily Safra Centre for Brain Sciences,<institution>The Hebrew University of Jerusalem</institution>, Safra Campus, Jerusalem,<country>Israel</country> 9190401;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurobiology, Institute of Medical Research-Israel Canada, Hadassah Medical School,<institution>The Hebrew University of Jerusalem</institution>, Jerusalem,<country>Israel</country> 9112001</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27671661</idno><idno type="pmc">5068334</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068334</idno><idno type="RBID">PMC:5068334</idno><idno type="doi">10.1073/pnas.1612392113</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000676</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000676</idno><idno type="wicri:Area/Pmc/Curation">000676</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000676</idno><idno type="wicri:Area/Pmc/Checkpoint">000085</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000085</idno><idno type="wicri:Area/Ncbi/Merge">002096</idno><idno type="wicri:Area/Ncbi/Curation">002096</idno><idno type="wicri:Area/Ncbi/Checkpoint">002096</idno><idno type="wicri:doubleKey">0027-8424:2016:Schechtman E:pallidal:spiking:activity</idno><idno type="wicri:Area/Main/Merge">000259</idno><idno type="wicri:Area/Main/Curation">000258</idno><idno type="wicri:Area/Main/Exploration">000258</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pallidal spiking activity reflects learning dynamics and predicts performance</title><author><name sortKey="Schechtman, Eitan" sort="Schechtman, Eitan" uniqKey="Schechtman E" first="Eitan" last="Schechtman">Eitan Schechtman</name><affiliation wicri:level="1"><nlm:aff id="aff1">Edmond and Lily Safra Centre for Brain Sciences,<institution>The Hebrew University of Jerusalem</institution>, Safra Campus, Jerusalem,<country>Israel</country> 9190401;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Noblejas, Maria Imelda" sort="Noblejas, Maria Imelda" uniqKey="Noblejas M" first="Maria Imelda" last="Noblejas">Maria Imelda Noblejas</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurobiology, Institute of Medical Research-Israel Canada, Hadassah Medical School,<institution>The Hebrew University of Jerusalem</institution>, Jerusalem,<country>Israel</country> 9112001</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizrahi, Aviv D" sort="Mizrahi, Aviv D" uniqKey="Mizrahi A" first="Aviv D." last="Mizrahi">Aviv D. Mizrahi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurobiology, Institute of Medical Research-Israel Canada, Hadassah Medical School,<institution>The Hebrew University of Jerusalem</institution>, Jerusalem,<country>Israel</country> 9112001</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dauber, Omer" sort="Dauber, Omer" uniqKey="Dauber O" first="Omer" last="Dauber">Omer Dauber</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurobiology, Institute of Medical Research-Israel Canada, Hadassah Medical School,<institution>The Hebrew University of Jerusalem</institution>, Jerusalem,<country>Israel</country> 9112001</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><affiliation wicri:level="1"><nlm:aff id="aff1">Edmond and Lily Safra Centre for Brain Sciences,<institution>The Hebrew University of Jerusalem</institution>, Safra Campus, Jerusalem,<country>Israel</country> 9190401;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurobiology, Institute of Medical Research-Israel Canada, Hadassah Medical School,<institution>The Hebrew University of Jerusalem</institution>, Jerusalem,<country>Israel</country> 9112001</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>The basal ganglia (BG) are a set of interconnected nuclei deeply buried within the brain that are involved in action selection and habit formation. Classically considered motor nuclei, their role in cognitive performance has become widely appreciated over time. Current models of learning in the BG focus on striatal neurons and the neurotransmitter dopamine, but these do not fully account for observed behaviors. In this paper, we considered the learning-related activity of the external globus pallidus (GPe), a downstream BG nucleus. We show that GPe spiking activity predicts future performance, corresponds with learning dynamics, and decreases as performance becomes more automatic. Taken together, our data reveal the role of GPe in learning and open new avenues for research.</p></div></front></TEI><affiliations><list><country><li>Israël</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Schechtman, Eitan" sort="Schechtman, Eitan" uniqKey="Schechtman E" first="Eitan" last="Schechtman">Eitan Schechtman</name></noRegion><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><name sortKey="Dauber, Omer" sort="Dauber, Omer" uniqKey="Dauber O" first="Omer" last="Dauber">Omer Dauber</name><name sortKey="Mizrahi, Aviv D" sort="Mizrahi, Aviv D" uniqKey="Mizrahi A" first="Aviv D." last="Mizrahi">Aviv D. Mizrahi</name><name sortKey="Noblejas, Maria Imelda" sort="Noblejas, Maria Imelda" uniqKey="Noblejas M" first="Maria Imelda" last="Noblejas">Maria Imelda Noblejas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000258 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000258 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5068334
|texte= Pallidal spiking activity reflects learning dynamics and predicts performance
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27671661" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |